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If you were looking for terms with many letters in Shakespeare’s language, you’ve come to the right place. Here are the 20 longest words in English and their meaning.

These words are generally related to different areas of knowledge. You will find words that are used in law, geology and medicine, but that you will eventually get if you are in an English-speaking social, academic or professional context.

Here are the 20 longest words in the English language that you can get in the Oxford Dictionary

The 20 longest words in English and their meanings

  1. Pneumonoultramicroscopicsilicovolcanoconiosis (45 letters): This word is a medical term referring to a lung disease caused by the inhalation of excess silica dust. In practice, doctors often call this disease silicosis because of the length of the word.
  2. Pseudopseudohypoparathyroidism (30 letters): Although it sounds complicated, this word is also related to medicine. It is a variant of the term pseudohypoparathyroidism, but is not linked to altered levels of calcium and phosphorus in the blood.
  3. Floccinaucinihilipilification (29 letters): Despite its length, this word has no medical connotations. Actually, it is a philosophical word meaning to consider something worthless or insignificant. Paradoxically, its definition is useful for mentioning long words.
  4. Antidisestablishmentarianism (28 letters): This term refers to opposition to the removal of the Church of England as the official state church.
  5. Honorificabilitudinitatibus (27 letters): Although rarely used, this word appears in Shakespeare’s play “Love’s Labour’s Lost”. Its meaning is “with honors”.
  6. Dichlorodifluoromethane (25 letters): A chemical compound that used to be used in refrigerants and aerosols. However, due to its impact on the ozone layer, its use has been reduced.
  7. Supercalifragilisticexpialidocious (34 letters): This word is famous from the movie “Mary Poppins”. It has no specific meaning, but is used to express something extraordinary or amazing.
  8. Hippopotomonstrosesquippedaliophobia (36 letters): Ironically, this word refers to the fear of long words. Its length is a paradox in itself.
  9. Electroencephalographically (27 letters): Related to medicine, this word describes something that is related to the recording of the electrical activity of the brain by means of an electroencephalogram (EEG).
  10. Otorhinolaryngologist ( 22 letters): A medical specialist who deals with diseases of the ear, nose and throat.
  11. Psychoneuroendocrinological (27 letters): This word refers to the study of the interactions between the nervous system, endocrine system and behavior.
  12. Immunoelectrophoretically (27 letters): Related to immunology, this word describes a laboratory method using electrophoresis and immunology.
  13. Hepaticocholangiogastrostomy (28 letters): A surgical procedure that creates a connection between the liver, gallbladder and small intestine.
  14. Antiestablishmentarianism ( 22 letters): Similar to the previous term, it refers to opposition to the existing establishment or system.
  15. Paraprofessionalism (18 letters): Describes the collaboration of unlicensed professionals or assistants in the field of health or education.
  16. Intercomprehensibilities (23 letters): The plural of intercomprehensibility, which refers to the ability to understand each other between speakers of different related languages.
  17. Counterdemonstration (18 letters): Refers to a demonstration or protest organized in opposition to another.
  18. Disproportionableness (19 letters): Describes the lack of proportion or inequality.
  19. Incomprehensibilities (21 letters): The plural of incomprehensibility, which refers to the state of impossibility or difficulty in understanding something.
  20. Supercalifragilisticexpialidocious. It’s the title of a song from the movie Mary Poppins, and refers to what you should say when you don’t know what to say. Yes, it appears in several dictionaries.

Extremely long English words

The above 20 words are the longest words in the English language that you could possibly come across in your life. But there are much longer ones in this language.

For example:

Methionylthreonylthreonylglutaminylalanyl…isoleucine. This superword actually has 189,819 letters, so here it is in its extremely abbreviated form. This is the chemical composition of titin, the largest protein known to date.

Or Methionylglutaminylarginyltyrosyltyrosylglutamyl…serine, which we abbreviate this way here but which has 1,909 letters, and is the chemical name for E. coli TrpA.

In any case, we hope that these long words in English have helped you to see from a broad perspective the richness of that language, and that -in no case- it discourages you from learning it because it is quite unlikely that you will have to use such terms.

In any case, take the plunge and learn English. And do it with Lingua Language Center. Our consultants are waiting for you to bring you to the United States or offer you our online English programs.